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Gastrointestinal effects are particularly common, especially during treatment initiation and dose escalation: Nausea classified as 'very common' (affecting more than 1 in 10 patients) in the SmPC [1] [2] Vomiting 'common' (affecting up to 1 in 10 patients) Diarrhoea 'common' according to the MHRA/EMC SmPC Constipation 'common', likely related to delayed gastric emptying Abdominal pain or discomfort 'common', generally mild to moderate in severity Decreased appetite 'common', which may lead to reduced food intake and weight loss (note that while weight loss can occur with Ozempic, it is not licensed for weight management in the UK) [1] [2] These gastrointestinal symptoms usually diminish over time as the body adapts to the medication

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However, a clinical study from 2022 reported that hair loss (alopecia) occurred in 4.9% to 5.7% of people using a 5 mg to 15 mg dose of Mounjaro, compared to 0.9% of those using the placebo

Impact Analytics, in its Retail Demand Reset report, estimates that for a billion-dollar retailer with a typical 20 percent return rate, a five-to-ten-point jump in returns erases about $20 million of gross margin, and that more than 400 million apparel units a year could be mis-sized by 2027, roughly $5 billion in capital and margin leakage