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The supply of GLP-1 drugs for weight loss and diabetes treatment is expected to tighten this week with a federal deadline to halt the sale and production of off-brand products that many patients in the United States have come to rely on

The rationale for a GLP-1 drug is its powerful body-wide and brain anti-inflammatory properties, says Eric Topol, a cardiologist and the director of the La Jolla, California-based Scripps Research Translational Institute, which is sponsoring the trial

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonists form classes of medicines that can help treat conditions such as type 2 diabetes and obesity

Injecting degraded peptide means injecting an unknown amount of active compound