efficacy of semaglutide tirzepatide versus in achieving therapeutic targets in type 2 diabetes: a post hoc analysis of the SURPASS-2 Trial | Diabetologia pioneer plus semaglutide Efficacy of
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Increased leptin also causes an increase in metabolic rate

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A 2023 study published in JAMA Ophthalmology examined over 16,000 patients and found a small but statistically significant increased risk of certain retinal complications in those prescribed semaglutide compared to other diabetes medications