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Each phase lasts approximately three months and is designed to build on the previous one, fostering gradual and sustainable changes

Bile acids trigger GLP-1 release predominantly by accessing basolaterally located G proteincoupled bile acid receptors. Endocrinology 156.11 (2015): 3961-3970

[3] Obesity-related respiratory conditions: Patients with obesity commonly have underlying respiratory disorders that may become more apparent during treatment

Clinical trials demonstrate significant weight reduction, with patients losing approximately 15% of body weight over 68 weeks with semaglutide (STEP 1 trial) and up to 21% with tirzepatide 15 mg over 72 weeks (SURMOUNT-1 trial)