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These symptoms may mimic more serious conditions, but are usually temporary and improve with relaxation techniques, breathing exercises, or professional support if anxiety is chronic

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SURMOUNT-1: Tirzepatide for Obesity The SURMOUNT-1 trial (NEJM, 2022) studied tirzepatide weight loss in 2,539 adults with obesity (without diabetes) over 72 weeks: STEP 1: Semaglutide for Obesity The STEP 1 trial (NEJM, 2021) studied semaglutide 2.4mg in 1,961 adults with obesity (without diabetes) over 68 weeks: Cross-Trial Summary Comparing across trials (with the caveat that indirect comparison has limitations): tirzepatide 15mg produced about 6 percentage points more weight loss than semaglutide 2.4mg over similar timeframes

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Nutrition and lifestyle Although GLP-1 agonists are a promising class of medications, they arent a cure-all

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Medicaid coverage of and spending on GLP-1s

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