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Description
Inhibitors of DPP-4 participate in the pancreatic-endocrine-osseous axis by increasing endogenous GLP-1
In the presence of a mixture of gabazine (20 M) and tetrodotoxin (1 M), application GLP-1 significantly increased frequency, but not amplitude of miniature EPSCs via PKA signaling pathway
As a result, many members turned to diabetes-indicated GLP-1s off-label, creating shortages that impacted patients who needed them for type 2 diabetes
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