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Description
Gut hormone PYY3-36 physiologically inhibits food intake

The BBB-crossing ability of liraglutide and lixisenatide has been successfully demonstrated, and they subsequently activate GLP-1 receptors in the brain

At these levels, the effects on gastric emptying, satiety, and decrease in food intake are seen
Therefore, phenotyping GLP-1R-expressing cells in the VTA and determining how GLP-1R activation alters activity of these neurons during cocaine seeking are essential next steps toward developing the next-generation of GLP-1R-based therapies to treat CUD
