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To start, drugmakers are experimenting with dosage

14,15 Potential Direct Effects on the Heart Although the systemic indirect effects of GLP-1RAs are well established as the primary drivers of their clinical benefit in HF, emerging preclinical and mechanistic evidence suggests GLP-1RAs may also exert some direct cardioprotective effects, as discussed below

Further evidence of defective energy metabolism in AD and PD is also adduced by studies showing perturbations in the expression and/or activity of mRNA translation machinery required for adequate protein synthesis [198]