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The combined therapy with liraglutide and metformin (COMBI) seems to be more effective

Candidate patient groups for such dual-treatment approaches may include IBD patients with elevated BMI, those at increased risk of metabolic complications, patients receiving therapies associated with heightened cardiovascular risk, and overweight individuals with IBD who are candidates for surgical intervention

A December 2025 study suggested that Trulicity may not impact a babys viability or affect the moms pregnancy hormones