glp-1/glp-2 dual agonist GLP-1/GIP | Tirzepatide | Obesity & T2DM Mx | Harrison's Update(22nd Ed.) TrimRX | GLP-1 vs GIP:

Choosing the right foods on semaglutide involves prioritizing protein to prevent muscle loss during weight reduction, eating smaller meals to accommodate reduced appetite and slowed gastric emptying, and avoiding foods that exacerbate GI side effects

Eli Lilly reported these results in mid-2025, and the retatrutide availability timeline now points toward potential FDA approval no earlier than 2027, as additional phase 3 trials continue

These medications work by: Slowing gastric emptying Increasing feelings of fullness Reducing hunger and food cravings Influencing reward pathways involved in eating behavior Because appetite, reward, and impulse control are closely tied to mental health, GLP-1s may affect emotional and psychological functioning in ways that go beyond weight loss alone

For context, in one study of 175 people with overweight or obesity, participants taking semaglutide: Lost an average of 15 pounds (about 6% of their body weight) within three months Lost an average of 27 pounds (about 11% of their body weight) after six months Recommended lifestyle changes during GLP-1 therapy GLP-1 medications can boost weight loss by increasing satiety and reducing food cravings