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These medications have reshaped how clinicians think about metabolic health, addressing not only body weight but also fatty liver, insulin resistance, and cardiovascular risk
After excluding patients with prior herpes infection and applying a new-use design, 155,793 GLP-1RA users and 138,295 DPP-4i users remained
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These accumulating data led to progressive updates and strengthening of international clinical guideline recommendations for the use of SGLT2-I and GLP-1 RA therapies throughout the study period
