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In a report out this week, doctors have detailed three cases of their patients developing anhedoniaan inability to feel pleasureafter they started taking tirzepatide for their obesity

Department of Health and Human Services (HHS), said in a statement

Compared to classical exenatide given twice daily (BID, the once-weekly (QW) formulation at a 2 mg dose level provides a relatively stable plasma concentration at steady-state (300 pg/ml) because of the more continuous delivery of the drug, with equal (or slightly improved) efficacy on glycemic control and body weight after 24 and 30 wk of treatment [888]

This dual mechanism affects both its efficacy and its timing requirements