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Effect of liraglutide therapy on liver fat content in patients with inadequately controlled type 2 diabetes: the Lira-NAFLD study

Other genetic loci: Polymorphisms in genes such as CNR1, CTRB1/2 andTCF7L2, have shown associations with GLP-1RA response, particularly liraglutide, affecting glycemic control and metabolic parameters [14,133,135]

47 SGLT2-I approved in the US for the treatment of T2DM include canagliflozin (Invokana, 2013), dapagliflozin (Farxiga, 2014), and empagliflozin (Jardiance, 2014)

However, most previous NMA studies have compared specific drugs (e.g., pioglitazone and rosiglitazone) or combinations of drug regimens (e.g., rosiglitazone+losartan, rosiglitazone+ metformin) rather than drug classes [38,39,42]