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Purpose of Review The development of long-acting incretin receptor agonists represents a significant advance in the fight against the concurrent epidemics of type 2 diabetes mellitus (T2DM) and obesity

Experimental receptor assays demonstrate that GLP-RTfunctions as an agonist at all three receptors, although the peptide exhibits differing potency levels across the receptor set

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We have assessed various metabolic parameters after short and long exposure of clonal BRIN-BD11 -cells and rodent islets to the GLP-1R agonist Exendin-4 (50nM)