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To account for possible confounders, such as age, sex, BMI, baseline metabolic parameters (HbA1c, fasting glucose, lipid profile), dietary practices, skincare regimens, physical activity, and concurrent drugs that may affect dermatological results, multivariate analyses were performed

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the high dose of permeation enhancer (SNAC) of 300 mg per tablet may cause gastrointestinal adverse reactions like nausea, abdominal pain and vomiting, see FDA approved package insert of Rybelsus
