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In contrast, truncation of the two extreme C-terminal residues (Arg 36 and Gly 37 ) resulted in a less dramatic effect, although potency was nevertheless reduced
The hydrophobic binding site of GLP-1R ECD is occupied by hydrophobic residues of both GLP-1 and Fab 3F52
Safety differences tend to be molecule and indication-specific rather than route-driven, and regulators evaluate benefitrisk case by case, Campbell said
