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Before considering any off-label combination approach, a comprehensive evaluation including genetic predisposition screening and biomarker assessment can help providers and patients optimize single-agent therapy

A 2026 study published in The Lancet Obstetrics, Gynaecology & Womens Health found that combining GLP-1 therapy with HRT produced greater mean weight loss than GLP-1 alone in this patient population

For healthcare professionals, this potential link underscores the importance of comprehensive patient education and close monitoring

Assuming standard FDA review timelines and no significant delays, approval could come as early as 2027