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The frequency reduction approach Some people and providers prefer to keep the dose the same but stretch out the interval between injections

[DOI] [PubMed] [Google Scholar] 79.Wenten M, Gaebler JA, Hussein M, Pelletier EM, Smith DB, Girase P, Noel RA, Braun DK, Bloomgren GL

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study
The precise cause of RLS is unknown, but researchers have their guesses
