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de Lartigue G, Ronveaux CC, Raybould HE

Discussion GLP-1/exendin-4 Suppresses GABA Currents of Rat GCs by Activating GLP-1R Although GLP-1 and GLP-1R agonists have been reported to regulate AMPA receptors and GABA A receptors in central neurons [14, 57,58,59,60], no data concerning the regulation of ligand-gated channels of retinal neurons by GLP-1/GLP-1R agonists were available

Clinical trials boast an average weight loss of 15 to 20 percent of total body weight when combined with lifestyle changes, positioning it as one of the most effective treatments available

Together, these two studies elucidate pathways that inform strategies coupling GLP-1R signaling to control of body weight in patients with diabetes or obesity