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& Harris, M
There is no data on the safety and efficacy of compounded tirzepatide alone or in combination with these other ingredients

GLP-1 agonists reduce appetite, modulate satiety circuits, alter hepatic lipid handling, improve endothelial function, attenuate inflammatory tone, influence microglial behavior, and appear to exert downstream neuroprotective effects, yet the field cannot convincingly articulate how these effects relate to one another, which are primary versus secondary, or which are merely correlative epiphenomena arising from broader systemic shifts

Serious adverse events were balanced across groups