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38.A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities (SURMOUNT-5)

GLP-1 class safety monitoring should include awareness of these important risks: Pancreatitis : Patients should promptly report severe abdominal pain, with or without vomiting Gallbladder disease : Report symptoms of biliary colic or cholecystitis Acute kidney injury : Maintain adequate hydration, especially if experiencing nausea/vomiting Hypoglycemia : Increased risk when used with insulin or sulfonylureas Suicidal ideation : For patients using Wegovy or Zepbound, monitor for mood changes Patients should be counseled to report any neck swelling, difficulty swallowing, persistent hoarseness, or palpable thyroid nodules, as these warrant evaluation regardless of GLP-1 use

La principal estructura del sistema nervioso central que participa en la regulacin del apetito es el hipotlamo, especialmente el ncleo arcuato y el ncleo paraventricular, los cuales reciben aferencias vagales y seales de los pptidos u hormonas tanto del sistema gastrointestinal como del tejido adiposo

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