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And as a result, there are pretty strict barriers to entry

These findings align with literature proposing multiple pathways through which semaglutide may act, mitigating vascular stiffening, adverse lipid profiles, inflammation, and endothelial dysfunction, alongside effects on glycemic control, insulin resistance, and weight loss [1, 4]

Mild-to-moderate side effects and drug mechanism The most common adverse events were mild-to-moderate gastrointestinal events, primarily during the dose escalation period

Gastrointestinal effects dominate: nausea, vomiting, diarrhea, and constipation, usually mild-to-moderate and worst during dose escalation