asa statement on glp 1 Anesthetic Considerations for Patients Taking Glucagon-Like Peptide-1 Agonists Glucagon-Like Peptide 1 Receptor Agonists

115 Compared with the structure of human GLP-1(7-37), the amino acid sequence of semaglutide contains diaminoisobutyric acid at position 8, arginine at position 34, and acylated lysine at position 26

A meta-analysis [74] including the ELIXA [66], LEADER [44], SUSTAIN-6 [67], EXSCEL [68], REWIND [70], and AMPLITUDE-O [51] studies found that GLP-1RAs were associated with better renal outcomes: a 30% or 40% or more decrease in glomerular filtration rate, need for renal replacement therapy, end-stage renal failure, or death from kidney disease by 21%

Additional glycemic control is needed, increase the dosage to 14 mg orally once daily

Large self-funded employers have increasingly been adding GLP-1 coverage as employee demand grows, but many smaller employers and fully insured groups have not, primarily because the cost impact on premiums is significant