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Allergic reactions to semaglutide, though rare, can occasionally present with injection site manifestations beyond simple bruising

Methods In this retrospective cohort study, 125 474 adults with overweight or obesity newly initiated treatment with a dual-labeled GLP-1 RA (liraglutide, semaglutide, or tirzepatide) between January 1, 2018, and December 31, 2023, with a baseline body mass index of 27 or more, an available weight measurement within 60 days before initiation, and regular care in the year before initiation were identified using electronic health record data from a collective of US health care systems

This mechanism operates continuously while you take the medication, but stops when you discontinue it

National guidelines: several go higher to 30g , including Germanys DGE, the UK, and France