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Interaction risk

The results of SELECT, which examined the effect of subcutaneous semaglutide injection for the prevention of cardiovascular events in 17,604 patients with obesity (body mass index [BMI] 27 kg/m 2 ) and established cardiovascular disease but without diabetes, were presented in 2023 [25]

Based on the encouraging efficacy of GLP-1/glucagon and GLP-1/GIP co-agonists, it was rationalized that a single molecule with triple agonism at all three of these receptors might provide even greater efficacy than the respective co-agonists

Several real-world studies based on administrative data and pharmacy reports have demonstrated that reduced adherence to antidiabetic therapy is associated not only with poorer glycemic control but also with a significant increase in overall mortality and hospitalizations for all causes [70, 71]