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Introduction Metabolic dysfunctionassociated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, affecting up to nearly 38% of the adult population [1]

This dual effect occurs through weight loss, direct GLP-1 receptor signaling in blood vessels, and improved insulin sensitivity

Significant weight loss can leave behind loose skin, stubborn fat pockets, or uneven contours that do not reflect the patients effort

This represents a more straightforward scenario for proceeding with incretin-based therapy in someone with previous gallstone disease, though standard contraindications still apply