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Researchers examining the full scope of that evidence can consult the Retatrutide Evidence Dossier for a structured summary of published findings

The only weight-loss medication available over the counter in the UK is orlistat 60 mg (sold as Alli)

Reported incidences included nausea (5.922.2%), diarrhea (8.825.3%), vomiting (2.99.1%), and constipation (8.816.2%), with discontinuation rates reaching 19% in high-dose monthly regimens (816 mg) [62,63,64]

Missed doses and frequent medication switches can affect side effects and stability during screening