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These gastrointestinal issues are usually mild and tend to decrease over time as the body adjusts to the medication

GLP-1 Agonists and Gastrointestinal Adverse Events JAMA Network

The mechanistic explanation: GLP-1 receptors are expressed in brain regions involved in reward processing specifically the ventral tegmental area (VTA) and nucleus accumbens (NAc), both central to the reinforcing effects of alcohol, food, and other substances

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