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Given the promising results in pre-clinical models (even in the absence of T2D), a unique mechanism of action and multiple age-related reduced disease risks that have been reported with acarbose, support for clinical trials with acarbose focusing on aging-related outcomes and incorporating biological sex, age at treatment initiation, and T2D-dependence within the design is warranted.

Upper respiratory tract infections (URTIs) were the most frequently reported adverse event (8 of 12 reporting studies, 66.7%), occurring at rates comparable to controls across RCTs (GRADE: MODERATE certainty)