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One potential link is the frequency of pancreatic duct replication, which is increased in humans with obesity and/or type 2 diabetes (24)

This so-called incretin effect is attributed to the insulinotropic action of gut hormones, particularly: Glucose-dependent insulinotropic polypeptide (GIP) Glucagon-like peptide 1 (GLP-1)
10.1007/s00395-015-0476-7 55 SampedroJ.BogdanovP.RamosH.Sol-AdellC.TurchM.ValeriM.et al (2019)

The key finding was a remarkable consistency in cardiovascular outcomes across both drug classes and individual agents
