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Conclusion Further prospective, longitudinal research is warranted to fully characterize these apparent promising effects of semaglutide for weight management, and their relationship with clinical outcomes.

GLP-1 receptor agonists (GLP-1RAs) show clinical promise, and the prevailing hypothesis is that their benefits are primarily driven by weight loss and the downstream benefits of improved functional status

Semaglutide side effects often emerge within the first week of dosing, peak around weeks 24, and vary based on individual tolerance, genetic predispositions, and baseline metabolic health