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2024;384 doi: 10.1136/bmj-2022-072686
Ventricular wall remodeling by scar-forming astrocytes and reactive glial changes were accompanied by disrupted Cx43 and AQP4 distribution patterns in the ventromedial hypothalamic nucleus
If the primary endpoint is symptom scales without prespecified phenotype strata (e.g., dysautonomia-dominant vs microvascular-dominant vs neuroinflammatory-dominant), signal dilution is a risk
