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Cardio- and reno-protective effects are unlikely to be solely explained by the mechanisms used by these drugs to lower blood glucose levels, as the same effects are not seen with drugs that have stronger antihyperglycaemic actions [111], and were not dependent upon the degree of HbA1c reduction [113,114,115]

If the patient is unable to hold the GLP-1 receptor agonist for at least 3 half-lives before the procedure, consider rapid-sequence induction of general anesthesia, to reduce the risk of aspiration, and consider the use of point-of-care gastric ultrasonography, where available, to check for residual gastric content

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Melatonin receptors: molecular pharmacology and signalling in the context of system bias