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Johnstone M, Buddhdev P, Peter M, Diggory R

The remarkable efficacy of new diabetes and weight-loss medicines like Ozempic and Mounjaro have been one of the biggest health stories in recent years

While individual results differ based on factors like diet adherence and physical activity, most patients notice changes in appetite within the first week and start seeing real weight loss by the fourth week

First, retrospective observational studies using patient EHRs can suffer from inherent limitations including over-/under-/mis-diagnosis, unmeasured or uncontrolled confounders and biases
