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Functional mushrooms are also sometimes called adaptogenic mushrooms because of their adaptogen content.34 Adaptogens are compounds found in certain mushrooms and botanicals and may help to reduce the negative effects of stress on the body.25 35 They do so by influencing three of your endocrine system organs the hypothalamus, pituitary gland, and adrenal glands, collectively known as the HPA axis to stop releasing excess stress hormones, like cortisol.36 Adaptogens may also regulate your bodys energy use and help it to maintain homeostasis