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Although these data are necessary and informative, it will be critical to better understand whether analogous effects are observed within a narrower window of changing leptin levels, as may occur during alterations of energy state or development in fed versus fasted states (RamosLobo et al., 2019)

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Lixisenatide requires a functional gut-vagus nerve-brain axis to trigger insulin secretion in controls and type 2 diabetic mice

Briefly, the first GLP-1RA started with administration twice-daily (BID
