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The most common adverse events are mild to moderate gastrointestinal symptoms, which may be mitigated through dietary counseling during dose escalation

However, anti-obesity medications are prescribed to only about 4% of eligible people due to concerns about safety or effectiveness, lack of health care provider training in weight management, excessive costs due to insurance companies refusing coverage, and a toxic stigma that portrays obesity as a lack of willpower

Long interested in Holst's work, in 1990 Novo Nordisk recruited his colleague Schwartz to develop small molecules able to activate the GLP receptor in the pancreas (Molteni, Chen)

Throughout this article, any reference to Tirzepatide for weight loss refers to Zepbound