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These receptors exist on pancreatic beta cells (which produce insulin), brain regions controlling appetite and reward, the stomaComparing Mechanisms of Actionch and intestines, liver, heart, and other tissues
The clinical spectrum of MASLD spans from simple steatosis, which is often benign and potentially reversible, to metabolic dysfunction-associated steatohepatitis (MASH), a progressive and inflammatory condition that may lead to hepatic fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) (2, 3)
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