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Fat Joe has shared that he once weighed around 470 pounds and has since lost over 200 pounds over time, crediting a mix of lifestyle changes and medical support

Doses start at 0.25 mg weekly, increasing every 4 weeks until reaching a maintenance dose of 2.4 mg weekly, if tolerated

In the SURMOUNT-1 trial with 2,539 adults with obesity, participants on the highest tirzepatide dose (15 mg weekly) lost an average of 20.9% of their body weight over 72 weeks

The stable drug levels prevent the peaks and valleys seen with medications that clear quickly, resulting in more uniform metabolic effects and better tolerability for most users