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In another double blind trial (PIONEER 6) which focused on cardiovascular outcomes, 3,183 patients with diabetes and obesity (mean BMI 32.3) were treated for 16 months

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PMID 38629387

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The standard recommendation has been lifestyle changes, such as adopting a lower-calorie diet and increasing physical activity

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When combined with intensive behavioral therapy, semaglutide produced significantly greater weight loss than behavior change alone, demonstrating that medication enhances rather than replaces lifestyle modification

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