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If youve missed multiple doses or youre struggling with side effects, check in with your prescriber for individualized guidance

Even brief periods outside the cold chain can shorten the medication's effective lifespan, which is why dedicated medication refrigerator space or a temperature-controlled cooler is recommended for patients receiving semaglutide injections

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Factors such as baseline body composition, pre-existing thyroid function, nutritional status, and environmental temperature all influence whether a patient experiences cold sensitivity