does semaglutide have long term side effects Weight-loss drugs are becoming more accessible, but are they always safe? Experts raise concerns about the misuse of generics and the risks of unsupervised use. From to long-term impact Is Ozempic a GLP-1 Medication?

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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Troke RC, Tan TM, Bloom SR

Although it is presently unresolved whether the gut microbiota plays a role in the effects of these peptide hormones, it has been speculated that host-gut microbiota crosstalk, facilitated by the production and signaling of bacterial fermentation end-products of dietary fibers (short-chain fatty acids), influences intestinal chemo-sensing and modulates the release and activity of gut peptides 27,28,29,30