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DA5-CH reduces inflammation markers such as TLR4, Iba-1, GFAP, NF-B, TNF-, and transforms the growth factor 1 (TGF-1) in MPTP mice, as well as the proinflammatory cytokines (IL-6 and IL-I) [187]

When assessing TH1- and TH2-related cytokines separately, we observed that females had higher levels of TH2-related cytokines than males (main effect of sex for TH2: F (1,55) = 4.615, R 2 = 0.083, p = 0.018), but not TH1-related cytokines, nor were there any other significant main effects or interactions present, although there was a trend towards a diet effect (main effect of diet: p = 0.060

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Weight-Loss Drug Also Protects against Heart Disease