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Khan, MD, University of Pittsburgh Medical Center Once-weekly semaglutide in adults with overweight or obesity, The New England Journal of Medicine (2021) Semaglutide for Type 2 diabetes mellitus: A systematic review and meta-analysis, Diabetes, Obesity and Metabolism (2018) About Dr

This case report describes two nondiabetic patients who developed acute foot drop after losing 14% and 18% of their total body weight over 36 months of semaglutide and tirzepatide use, respectively

The mechanisms, evidence base, and expected outcomes are fundamentally different

Resources such as the SAMHSA National Helpline (1-800-662-HELP) can provide treatment referrals, and patients at risk for opioid overdose should be prescribed naloxone
