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The etiology of HIT is primarily related to genetic polymorphisms of DAO or HNMT, diseases associated with DAO or HNMT deficiency, dysbacteriosis, drugs that inhibit DAO activity, foods rich in histamine, foods that inhibit DAO, and foods that promote histamine release

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A robust pipeline of entero-pancreatic hormone-based therapies is currently in development, with several dual and triple agonists expected to emerge for obesity in the coming years

April 1, 2026: More People Join Federal Litigation Over Side Effects from Zepbound and Other GLP-1 Drugs As of April 1, 2026, there are 3,546 pending claims in MDL 3094 ( IN RE: Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs) Products Liability Litigation )