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10.1016/j.bbr.2012.09.021 275

13 An increase in the use of GLP1 RA as initial treatment in drugnaive patients has been observed in Denmark 14 regardless that no randomized clinical trial evidence has been published on how or whether GLP1 RA outperforms metformin in these patients

GLP-1 GLP-1 GLP-1 GLP-1 GLP-1// 24 () GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 1 GLP-1 GLP-1 2 GLP-1 3 GLP-1 4 GLP-1 GLP-1 1 2 GLP-1 3 GLP-1 4 () 5GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 24 () 100%

The overall program size was influenced by regulatory guidance to establish substantial evidence for an indication, including minimum patient exposures for a weight management indication, the desire to include participants with and without T2D, and conduct of at least two wellcontrolled trials for each indication (weight management, OSA and OA)