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Although patent 780 specifically claims the method of treating diabetes mellitus, it also discloses how the compounds, including tirzepatide, can be used to treat other indications, including obesity and increasing bone strength

4-6% placebo Diarrhea: 12-17% Vomiting: 5-10% Constipation: 6-11% Decreased appetite: 5-11% GI events are predominantly mild-moderate and occur mainly during dose escalation (first 4-8 weeks), with significant attenuation over time Serious adverse events of interest : Pancreatitis : Adjudicated pancreatitis events occurred at rates of approximately 0.1-0.2% across the SURPASS program, comparable to rates seen with GLP-1 agonists

Morning dosing disrupts this alignment and reduces the physiological efficiency of the protocol