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98 Although located in the sinoatrial node, GLP-1 RAs influence the cardiovascular system through several other mechanisms, including the use of myocardial glucose, improvement of left ventricular function, myocardial ischaemic protection, increased heart rate, vasodilation, anti-atherosclerotic effects, and blood pressure reduction
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The GLP-1 surge has become a proving ground, one that may influence how CDMOs and pharma companies approach scale, flexibility, and speed of execution well beyond this therapeutic class
The authors suggest further randomized controlled trials to explore the therapeutic potential of GLP-1 agonists and GIP/GLP-1 combination drugs to treat alcohol use disorder, which affects 5.9 percent of individuals in the United States ages 12 and older
