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Besides lowering blood glucose, Lixisenatide improves cardiovascular health, delays stomach emptying, protects pancreatic beta-cells, and increases insulin messenger RNA (mRNA) expression and hormone release [237], [238]
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The currently ongoing SUMMIT trial (A Study of Tirzepatide in Participants With Heart Failure With Preserved Ejection Fraction and Obesity

The specific indicators of this improvement were: increased cardiac output, stroke volume, and peripheral muscle oxygenation
