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Gastroenterology 141 , 150156 (2011)

The First Wave: Older GLP-1 Medications Before semaglutide stole the spotlight, several other GLP-1 agonists were used primarily for diabetes management, with modest weight loss benefits

Other studies, however, report failure of GLP-1 to directly accelerate contraction in isolated adult rat cardiomyocytes, notably despite GLP-1 stimulation of cAMP accumulation [627]

It does not resolve what the right decision is for any individual - that conversation belongs with a licensed provider who can discuss both FDA-approved and compounded options in the context of your specific health history and goals